What if every choice we ever make was already made for us? What if there really were no coincidences in life and our destinies were already predetermined?

Ten strangers with secrets are brought together in a savage rainstorm: A limo driver (John Cusack), an '80s TV star (Rebecca DeMornay), a cop (Ray Liotta) who is transporting a killer (Jake Busey), a call girl (Amanda Peet), a pair of newlyweds (Clea DuVall and William Lee Scott) and a family in crisis (John C. McGinley, Leila Kenzle, Bret Loehr), all take shelter at a desolate motel run by a nervous night manager (John Hawkes). Relief in finding shelter is quickly replaced with fear as the ten travellers begin to die, one by one. They soon realise that, if they are to survive, they'll have to uncover the secret that has brought them all together.