Five years ago a deadly infection spread throughout the earth and ravaged its victims, changing them and mutating them to the ranks of the undead. Alice (Milla Jovovich) is still tirelessly searching for survivors and is helped by an old friend.

The dreaded Umbrella Corporation are out to get Alice and the vendetta between the two escalates; there are rumours that a few survivors have found refuge in Los Angeles, but once there, Alice and her crew find that the city has been overrun with zombies; they’ve just stepped into an unexpected ambush.