Dern plays Nikki Grace, an actress preparing for her biggest role yet; a Hollywood movie from an acclaimed director (played by Jeremy Irons) opposite an amourous leading man (Justin Theroux). But when she finds herself falling for her co-star, she realizes that her life is beginning to mimic the fictional film that they're shooting. Adding to her confusion is the revelation that the current film is a remake of a doomed polish production, 47, which was never finished due to an unspeakable tragedy.